For the 12a, the flanges and alignment on the ISC header are basically identical to the RB unit. When I swapped over, the ISC bolted right in with no changes. I assume that the 13B from ISC will also drop right in, too.
The advantages are as noted above. I got a non-stainless ISC and, in addition to weighing about half of what the RB header does, I haven't burned out the front tube after three years (~40 races). The RB, despite having twice the wall thickness, would barely make it a year. The ISC header is a first rate piece.