After several years in the tire business, I saw many things happen to trailer tires and motor home tires that are very similar. Usually, the result was a peeoed customer that couldn't grasp the concept of dry rot and maintained air pressure.
Rubber, whether natural or synthetic, is designed to flex. If it sits up, as do most motor home and trailer tires, it develops a type of "arthritis". The less it flexes, the harder it gets, and that leads to premature aging, cracks, and shucked treads/slow leaks. Almost all catastrophic failures of a tire are a result of loosing air pressure. While this sounds overly simple, it doesn't necessarily happen suddenly. All tires are subject to pressure loss with the changing of atmospheric conditions. Add to that the age and neglect involving most trailer tires, and you set yourself up for a problem.
Heavier ply tires, such as trailer tires, also build up heat...the true enemy of tires. My trailer came with 6 ply, trailer tread tires. They were incredibly heavy and thick. If I'd been towing a vehicle similar in weight to a Rolls or a medium sized truck, they would do the job fine. As it was, they were overkill. The heat generated by them and their seldom use would translate into trouble down the road.
I took them off and replaced them with passenger car tires of a shorter, wider dimension. This may sound like heresy, but I've been doing it for years, with two different trailers. I shared the first with my car partner, and had only a very little trouble with the tires. ALL the problems (few) I had with tires on that trailer could be traced back to my partner loaning it out to people that abused it, and his towing it through a virtual mine field of screws, nails, etc. This that may not have immediately shown, but down the road led to tire failure. Now that I have my own trailer, it's used only by me for its intended purpose...no others, and it's parked in a nice, clean driveway.
Trailer tires take a lot of bouncing that passenger cars don't. Unless you have a large trailer with some sort of shock absorber system, then your trailer bounces much more than your tow vehicle as it travels, thereby causing more flex in the sidewalls of the tires, building up more heat, and leading to failure. Add to that their difference in turning arc in relation to the tow vehicle (they tend to catch curbs, edges of pavement, stones, etc.), and you subject them to more opportunities to failure. Also, if you tow with a tandem axle trailer (hopefully), then the tires do an ENORMOUS amount of twisting in every turn. They are designed to travel fore and aft with only a small amount of side load in their lifestyles.
All this leads to a shortened life span. Best advice is to get a good tire, maintain the (cold) tire pressure to the maximum molded on the sidewall, investigate whether or not you need a true, heavy, trailer tire, and change them out every five years...whether they are short on tread or not.
It's worth it when the alternative is changing a blown out tire on a loaded trailer on the side of the road in the night in the rain after a long weekend of racing. (voice of experience)
Long, but hope I helped.